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Jonathan G Hardman BMedSci (Hons) BM BS CCST (anaes) DM FANZCA FRCA MEWI |
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The Nottingham Physiology Simulator |
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The Nottingham Physiology Simulator has been in continuous development since 1994 at the University Department of Anaesthesia in Nottingham. It uses a bottom-up approach to modelling several body systems, but, most importantly, the respiratory system. Currently, the NPS is provided “as is.” In other words, no technical support is provided. The software is written for academic purposes, rather than for commercial gain. Visitors to the site are welcome to download the most recent incarnation of the NPS. Versions of the NPS that have been used in specific modelling projects may be obtained by emailing me. I hope you enjoy using the NPS. Jonathan Hardman, September 2005
Recent publications that have used the NPS
Full papers in peer-reviewed journals Hardman JG, Bedforth NM, Ahmed AB, Mahajan RP, Aitkenhead AR. A physiology simulator: validation of its respiratory components and its ability to predict the patient’s response to changes in mechanical ventilation. British Journal of Anaesthesia 1998; 81(3): 327-32. Hardman JG, Bedforth NM. Estimating venous admixture using a physiological simulator. British Journal of Anaesthesia 1998; 82(3): 346-9. Hardman JG, Aitkenhead AR. Estimation of alveolar deadspace fraction using arterial and end-tidal CO2: a factor analysis using a physiology simulation. Anaesthesia and Intensive Care 1999; 27: 452-8. Bedforth NM, Hardman JG. Predicting patients’ responses to changes in mechanical ventilation: a comparison between physicians and a physiological simulation. Intensive Care Medicine 1999; 25(8): 839-42. Hardman JG, Wills JS, Aitkenhead AR. Investigating hypoxemia during apnea: validation of a set of physiological models. Anesthesia & Analgesia 2000; 90: 614-8. Hardman JG, Wills JS, Aitkenhead AR. Factors determining the onset and course of hypoxemia during apnea: an investigation using physiological modelling. Anesthesia & Analgesia 2000; 90: 619-24. Hardman JG, Aitkenhead AR. Validation of an original mathematical model of CO2 elimination and dead space ventilation. Anesthesia and Analgesia 2003; 97(6): 1840-5 Hardman JG, Aitkenhead AR. Estimating alveolar dead space from the arterial to end-tidal CO2 gradient: A modeling analysis. Anesthesia and Analgesia 2003; 97(6): 1846-51 McNamara MJ, Hardman JG. Hypoxaemia during open-airway apnoea: a computational modelling analysis. Anaesthesia 2005;60(8):741-6 Moppett IK, Gornall CB, Hardman JG. The dependence of measured alveolar deadspace on anatomical deadspace volume. British Journal of Anaesthesia 2005; 95(3):400-405
Abstracts (during last 4 years) Hardman JG, Meyer-Witting M, Goonetilleke PH. A modelling investigation of effect-site target-controlled propofol infusion. Anaesthesia and Intensive Care 2001. Bignell SJ, Hardman JG. Modelling the influence of infusion rate on effect-site target-controlled induction of propofol anaesthesia. Anaesthesia and Intensive Care 2001. Hardman JG, Bignell SJ, Lipman J. Alveolar pressures in a model of heterogeneous lung during positive pressure ventilation. Anaesthesia and Intensive Care 2001. Hardman JG, Bignell SJ. Modelling the influence of differing partition coefficients on effect-site target-controlled induction of propofol anaesthesia. Anaesthesia and Intensive Care 2001. Davies JA, Hardman JG. Alveolar recruitment-derecruitment and peak volume-acceleration in modelled ARDS lung. British Journal of Anaesthesia 2003; 90:411P Gornall CB, Moppett IK, Hardman JG. The dependence of measured alveolar deadspace on airways deadspace volume. British Journal of Anaesthesia 2003; 90(3): 412P-413P Knight DJW, Moppett IK, Hardman JG. The effect of varying inspired oxygen fraction on respiratory dead space and partial pressure of arterial carbon dioxide: a modelling study. British Journal of Anaesthesia 2003; 90(6): 828P-829P Knight DJW, Moppett IK, Hardman JG. Predicting carbon dioxide retention in acute exacerbations of COPD. Thorax 2003; 58(s3): 16. Knight DJW, Moppett IK, Hardman JG. A model of respiratory drive in acute exacerbations of COPD. British Journal of Anaesthesia 2004; 92(2): 308. Banks A, Moppett IK, Fletcher R, Hardman JG. The influence of anatomical shunt on alveolar dead space fraction. British Journal of Anaesthesia 2004; 93(1): 160P-161P Banks A, Hardman JG. The interaction of carbon dioxide production and anatomical shunt on the Bohr-Fowler alveolar deadspace fraction. British Journal of Anaesthesia 2005; 94 (3): 400P-400P Ingram K, Hardman JG. The variability of indices of oxygenation. European Journal of Anaesthesia 2005; in press
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